Gene Editing/CRISPR Scientist

Full Time

GrittGene Therapeutics is looking for:  Gene Editing Senior Research Associate 

GrittGene Therapeutics is looking for a Senior Research Associate. The ideal candidate will be adept at executing focused research activities to support the development of CRISPR-Cas9 based gene editing therapies. The candidate will work together with other Scientists and Research Associates to develop novel gene editing tools and to evaluate and advance lead assets for our therapeutic programs. The Senior Research Associate is expected to complete work in a resourceful, proactive and timely manner.

GrittGene Therapeutics general information about company mission & goals: 

1 in 4000 people worldwide could be affected by a Myotonic Dystrophy Type 2 which is a rare disease: that's more than 1.5 million people all over the world! At GrittGene Therapeutics, our Mission is to cure patients with Myotonic Dystrophy Type 2. In our hands, alleviation of disease symptoms is just an observable effect of the cure. We develop the cure of tomorrow by combining all the tools available today. With our disease-centric approach, with the cure being the main driving force, GrittGene’s interdisciplinary platform is free from the constraints of big pharma. The collaborative environment at GrittGene combines the power of expert scientists from various branches of the pharmaceutical industry. We employ cutting-edge technologies including CRISPR and Artificial Intelligence to achieve unprecedented tissue-specific delivery of small-molecule treatment and gene-specific editing. We are not limited by internal technology; we are free to develop treatment the right way through collaboration and a combination of the complete pool of technologies and wealth of knowledge at our disposal today.

With the freedom to use a wide range of expertise and experiences through collaboration with the private sector, clinicians and academia we are armed with the technologies to be used to achieve a singular goal, CURE.

Our goal is to provide a collaborative platform where the accumulated Knowledge, Experience, Relationships, Networks & Partnerships will come together to accomplish our mission.

Job Summary: The responsibilities include but are not limited to: 

  • Perform in vitro and cell-based studies to develop novel CRISPR-based gene therapies for Muscular Dystrophy Type 2
  • Apply molecular and cell biology techniques to screen/identify lead guide RNA candidates
  • Conduct Next-Generation-Sequencing assays to assess On-Target and Off-Targets gene editing efficiency
  • Grow commonly used cells and disease relevant cells in tissue culture
  • Purify nucleic acids from different sources using state-of-the-art technologies
  • Analyze nucleic acids quantity and quality with real-time PCR and gel/capillary electrophoresis
  • Measure gene editing efficiency and identify profiles using Sanger Sequencing
  • Troubleshoot challenges arising during protocol execution and identify opportunities for protocol and/or process improvement
  • Effectively collaborate and communicate with a highly integrated research team
  • Maintain clear and complete experimental records


Minimum requirements (Job Qualifications):

  • BS or MS (or equivalent degree) in molecular and cellular biology, biochemistry, genetics or related discipline with post graduate experience/ relevant employment experience (1-4 years for BS or 0-2 years for MS).
  • Extensive hands-on experience with molecular biology, cell culture, nucleic acids and protein analysis, assay development and data analysis
  • Previous experience with Next-Generation-Sequencing and/or CRISPR-based gene editing methods is a strong plus
  • Ability to work effectively as a member of a multidisciplinary team in a highly collaborative environment or independently when needed.
  • Commit to self-development and self-improvement in various aspects
  • Strong interpersonal, organizational, and documenting skills

EEO Statement:  
GrittGene Therapeutics is Equal Opportunity Employers and takes pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion, or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status 

Our Team, Values, and Culture: 

We are building a diverse, interdisciplinary team of dreamers and doers. Forget incrementalism and leave low-risk ideas at the door. We’re looking for fellow visionaries hungry for real impact in reimagining every facet of how we cure disease. Some of our values: first principles thinking, burning passion, and a drive to work with like-minded people; thinking outside the box and the ability to envision that which has not yet been built; listen, then talk; don’t forget to have fun; cooperation, trust, ethics, and transparency.   

An exciting opportunity to join early stage start up biotech company: 

As experts in human drug discovery, we have worked hard to position the company for success and to expand our team. You’re joining an incredibly ambitious team at an early enough time to help us define our culture, choices, and success. We will have the highest expectations of you, just as we do of ourselves. Join us in building new generation therapeutics outside of ordinary constrains! 

Apply this position